News & Reviews

The Most Effective CBD!

Here at Great Lakes Hemp Supplements we take pride in the education we can pass along. In today’s CBD market there is a great deception. This is due to the lack of regulation in the CBD market, as well as (if not more so) a general lack of education. In this article we will dive into what the differences are between a CBD Isolate vs Full Spectrum CBD extract, and the dichotomy of medicinal benefits between the two.

There is some general knowledge that is important to understand in order to talk about and compare these two types of products. In any given cannabis plant there exists special little chemicals called cannabinoids. Theses chemicals interact with your body and mind in a variety of different ways. To date there have been over 110 identified, the most abundant of which are THC (tetrahyrocannabinol), and CBD (cannabidiol). Where as THC is widely responsible for the 1960s; psychoactivity, euphoria, etc, CBD causes no psychoactivity, and actually works to counteract the psychoactivity of THC (in most cases). When extracting these chemicals from the plant, colloquially full spectrum means during the extraction process you pull a spectrum of all types of cannabinoids found in the source plant, where as an isolate pulls just one type of cannabinoid.

So whats the big deal? If CBD is so medicinal promising why not just make an extract packed full of only that? Seems simple right? Perhaps not nearly as simple as we would  think. Yes, it is true that CBD hosts the majority of medicinal benefits from the cannabis plant (or at least the greatest diversity), and yes it is true that you can achieve a very pure and simple product using only isolated CBD, however; research has shown that a cascade (entourage) effect occurs with the presence of additional cannabinoids (as found in a full spectrum vs an isolate) increasing the effectiveness astronomically.
In 2015 an incredibly important study was published out of the Lautenberg Center for General and Tumor Immunology in Jerusalem. The study examines exactly what we are discussing today: is a full spectrum CBD product more effective than an isolated CBD product and why. Directly from the study…

“Cannabidiol (CBD), a major constituent of Cannabis, has been shown to be a powerful anti-inflammatory and anti-anxiety drug, without exerting a psychotropic effect. However, when given either intraperitoneally or orally as a purified product, a bell-shaped dose-response was observed, which limits its clinical use” (source)

This bell-shaped dose-response means that only at a certain level of dosing – which would vary between individuals – is the isolate effective, at any higher or lower doses it is ineffective. In contrast to this the study found that a full spectrum CBD extract containing a high percentage of CBD with other trace cannabinoids proved to be wildly more effecting in alleviating inflammation and pain sensations at any dosing.
As part of this study there were tests performed on ethically-approved mice from the Hadassah Medical School. One of these tests was concerning the infamous anti-inflammatory properties of CBD. The graph below illustrates the effectiveness of CBD versus the 202 full spectrum extract when handling TNFa (tumor necrosis factor alpha) which causes fluid accumulation in body tissues (swelling). Both when performed orally and by injection the full spectrum extract proved to be more effective at any dosing, where as the isolate only performed comparatively at a single dosing.

In these graphs “Clone 202” refers to the full spectrum extract provided by the Tikun Olam Company, whereas “CBD” refers to the isolate provided by the THC Pharm GmbH.

(source)

As illustrated, the 202 extract preforms increasingly better as you increase the dosing, where as the CBD isolate is only really effective at a single dosing. Clinically this would be an incredibly shackling attribute, as dosing (especially with cannabis) is incredibly tailored to you and your body’s homeostasis – what works for one person may not work well for you at all. Isolates being extremely limited in dosing adjustments means we could not provide, or even recommend an educated opinion on where to start because if you don’t hit the nail on the head you will have missed out on most all the benefits you could and should achieve with CBD and cannabis extracts.
It is for these reasons we only use full spectrum extracts in our products instead of isolates; they are prolifically more effective, promote health diversely within the body, and coupled with naturally occurring terpenes, Full-Spectrum CBD is a natural and proactive medicine. Research what you’re putting into your body, especially if it isn’t clearly stated on the bottle/packaging, you could be losing over 90% of what you paid for!

We highly recommend you check out some of the articles we have included below for more information, and as always if you have any questions please email us directly at glhempsupplements@gmail.com, your education is our priority.

 

Rohan Django-Ashlin Berst
Executive manager GLHS


 

For original Lautenberg study click here
F
or a more in-depth review of the study click here
For more information on the “entourage” effect click here

 

 

Kingsley DDA Gives Thumbs up to TheraCann

http://www.record-eagle.com/news/local_news/kingsley-dda-supports-medical-marijuana-project/article_39adda0d-0f08-55dd-b702-b6af497f81de.html

This was a very interesting meeting as the Kingsley DDA unanimously gives approval to the TheraCann Project. The overwhelming support from the community in Kingsley was great to see.  As a Kingsley graduate and activist in the Medical Cannabis Community I have mixed feeling on this topic. I worry about the fact that it is TheraCann’s idea to not include a provisioning center in the plans. They are not encouraging Kingsley to have dispensaries in their zoning. Why is that? Is it to have a better chance of getting the project approved? Is Kingsley really going to allow a State of the Art facility to produce high quality medicinal cannabis in their village and not allow its residents to access it? My second main concern is will Mr Goodman keep his word and continue to rent these state of the art facility spaces to local caregivers to provide high quality medical cannabis to their patients? I heard Mr. Goodman state that any caregiver in Michigan can apply. There will be a very thorough vetting process though he stated. This means that all of the jobs could potentially go to people outside of our community and not to local farmers. As a Kingsley native I see the need and great benefit of bringing in the experience, knowledge, and taxable value this project can bring to the Village of Kingsley. in lies my mixed feelings. This Approval is ONLY symbolic in looking at the economical impact to the DDA.  This is not the final say or go ahead on the project. This only helps the zoning and planning commission to look at the project and begin their necessary process.

CBD Brings Hope for People with Epilepsy

Desperate parents across the Country who have children suffering with uncontrollable epilepsy are clamoring for more information on a marijuana strain rich in cannabidiol (CBD) – the major non-psychoactive ingredient in Cannabis, as the positive outcomes for many children using the treatment spreads throughout the media.

The serious long- term effects that accompany the use of anti-epileptic drugs and a lifetime of intractable seizures cannot be ignored. Despite the critics instilling fear that CBD-rich cannabis extracts can increase the risk of serious psychiatric disorders and long-term cognitive problems. The successful results that many patients suffering from epilepsy have been experiencing from CBD-rich cannabis extracts, such as a dramatic decrease in the number and frequency of seizures is therefore giving so many parents what they have been lacking for so long – hope.

While there may be some harmful effects from these CBD-rich cannabis extracts, they must be weighed against the very real dangers and challenges a constantly seizing child faces every day. Many people with severe epilepsy have tried a myriad of mind-numbing medications, brain surgeries, risky implanted electrical stimulation devices, diets and alternative therapies, with little to no relief of their symptoms. A child who has no other treatments left to try has some parents moving to States that offer legal CBD treatments.

Scientists and physicians have been quick to warn of the dangers of the marijuana extract because CBD use in people with epilepsy has yet to be clinically evaluated, due in part to the tight restriction the FDA and DEA have placed on cannabis and its compounds. It is currently classified as a Schedule 1 drug – the strictest level of regulation for a controlled substance.

We at GLHS & The Center for Compassion we believe that there must be more research done on cannabis rich in CBD. Currently, regulatory hurdles make it difficult for researchers to gain access to cannabis rich in CBD, but it is not impossible. There is no debate that the hoops researchers must jump through to obtain access to cannabis, or any chemical found in it, are hindering scientific advancement, while GLHS and The Center for Compassion is committed to helping researchers overcome these obstacles to advance research in this important area.

GLHS and Center for Compassion recognizes that CBD and/or medical marijuana are not an answer for all children with epilepsy. Much more needs to be done to find treatments and a cure for all forms of epilepsy, which affects more people than multiple sclerosis, cerebral palsy, muscular dystrophy and Parkinson’s combined – yet receives fewer federal dollars per patient than each of these. But parents and researchers are cautiously optimistic that this may be a promising new treatment on the horizon for some people. In fact, in true scientific spirit, scientists would no doubt desire to test not only pure CBD, but also high CBD/low THC cannabis, pure THC and other types of medical marijuana in epilepsy in order to clearly define the efficacy of these and other combinations on seizure control and the genesis of epilepsy.

Unfortunately, time is not on the side of many of these children with unrelenting seizures. Of course parents are going to do anything they can to help their children, even face the unknown, because the effects of long term, uncontrolled seizures are known – continued regression, intellectual disability, and even death. Safety and efficacy studies will take years to complete, and rightly so, but until then, compassionate use should be made available to the families suffering from severe, intractable epilepsy.

Please Refer to

What Is CBD’s Effect On Brain Degradation?

According to the National Institute of Alcohol Abuse and Alcoholism (NIAAA), alcohol can be linked to the breakdown of neurons, which are brain cells that communicate with each other to transmit signals among other effects. Due to the fact that cannabidiol (CBD) has been found to potentially have neuron protective properties. a study aiming to explore the effect of cannabidiol topicals on alcohol-induced brain degradation was recently published in Pharmocology Biochemisty & Behavior.

It is important to understand the causes of, and ways to prevent, degradation associated with excessive alcohol use, because some believe that the behavioral and cognitive deficits it causes may be linked to alcoholism’s high relapse rate. The researchers, who were from the University of Kentucky, AllTranz Inc., and the University of Maryland, hoped to compare a cannabidiol topical with a direct injection of CBD.

Cannabidiol (CBD) Topicals May Be Equally As Effective

Fluoro-Jade B (FJB) is a “degenerative stain” that is used to signify cell degradation in the central nervous system. In looking at the levels of FJB in the brain, researchers were able to determine the effects of 3 different cannabidiol gels (5% CBD, 2.5% CBD, and 1% CBD), and evaluate their neuron protective properties.

The initial results inspired the researchers to create a second generation of 2.5% gel, and they compared it with a direct injection of cannabidiol. Rats who were not treated topically were injected with 40mg/kg of CBD every day, and the results were comparable. In fact, the topical CBD treatment had better results in terms of protecting the brain from degradation.

The American study suggests that topical cannabis extracts may be an equally effective method of introducing cannabinoids to the bloodstream. This is particularly interesting, because cannabidiol topicals would eliminate the cancer-causing compounds associated with smoking cannabis flowers, similar to vaporizing (which reduces, but does not eliminate, the amount of cancer-causing compounds in cannabis smoke) and medicated edibles.

More studies are surely needed, but researchers believe that these results could be the beginning of a new aid for the treatment of alcoholism. Cannabis has been investigated for its reduction of opiate withdrawal symptoms, and it seems like it may expand it’s rehabilitation repertoire in the form of a cannabidiol topical.

Please Refer to our catalog for information regarding our CBD Topical Treatments!